Formulation and Characterization of Solanum lycopersicum Extracts for Anti-depressant Activity

Abstract

Depression is a multifaceted mental health disorder characterized by persistent feelings of sadness, loss of interest or pleasure in activities, changes in appetite or sleep patterns, low energy, and difficulties in concentration or decision-making. It is a significant global health concern, affecting people of all ages and backgrounds. This abstract explores the problem of depression by examining its prevalence, risk factors, impact on individuals and society, and available treatment options. Depression affects a substantial portion of the global population, with estimates suggesting that more than 264 million people worldwide experience depression. It is a complex condition influenced by a combination of genetic, biological, environmental, and psychological factors. Common risk factors include a personal or family history of depression, chronic medical conditions, substance abuse, significant life changes or stressors, and social isolation. Most of the antidepressant agents like moclobemide, amitriptyline etc are used for depression . However, most drugs still induce adverse effects. These disadvantages motivate to find a herbal treatment for depression.