Development Of a Simulation Based Mapping System for Rapid Identification of Acute Febrile Illness Associated Comorbidities

Abstract

Infectious diseases, especially febrile illness, continue to be a major cause of morbidity and mortality in these areas. Acute febrile illness (AFI) is a non-specific term used differently in clinical and public health contexts. Research on the etiology of AFI is important in directing appropriate empiric treatment and case management, prioritizing resources, developing prevention and control measures, identifying novel pathogens and outbreaks, and supporting global health security goals. An observational cohort study was conducted to characterize various indicators associated with AFI and other concomitant conditions/diseases through blood profiling. Acute febrile illness (AFI) is a clinical syndrome characterized by fever and other non-specific symptoms. Diagnostic AFI refers to infectious diseases that can be diagnosed through laboratory testing. The present study aims to conduct a relative analysis of key laboratory parameters of acute febrile illness (AFI) with comorbidities. It will examine various haematological parameters in different age groups with specific comorbidities and assess how these variables change in relation to the established etiology of AFI. The study was conducted retrospectively at Yatharth Hospital in Greater Noida, Uttar Pradesh, India, and was an observational patient registry study. All patients admitted to the hospital with a fever and staying at least 24 hours were evaluated. Complete blood count, liver function tests, and kidney function tests were performed, and lab investigation data were used for analysis. The result demonstrated that 211 hospitalized patients with fever, with a median age of 39 years and 56% males. Out of the 1819 patients in our current epidemiology study, 211 individuals were estimated to have different etiological causes of acute febrile illness. AFI including Respiratory tract infections (30.34%), Acute gastroenteritis (19.90%), UTI (9.95%), Diabetes mellitus (6.16%), Hypertension (5.21%), Cerebral Vascular Accident (4.73%), Liver Disease (3.79%), Chronic Kidney Disease (CKD) (3.79%), Colitis (3.79%), Thrombocytopenia (3.79%), Sepsis (2.36%), Viral (1.89%), Tuberculosis (1.89%) and Others (2.36%) are the reported co-morbidities.